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Symptoms: Rifampicin: Nausea, vomiting, abdominal pain, enlargement of the liver, jaundice, elevated liver enzymes, possible acute pulmonary edema, lethargy, clouding of consciousness, convulsions, generalized pruritus, brownish-red or orange discoloration of the skin, urine, sweat, saliva, tears and feces.
Isoniazid: Early manifestations (within 30 min to 3 hrs): Nausea, vomiting, dizziness, slurring of speech, blurring of vision and visual hallucinations. With marked overdosage: Respiratory distress and CNS depression, progressing rapidly from stupor to profound coma, severe, intractable seizures. Severe metabolic acidosis, acetonuria and hyperglycemia are typical laboratory findings.
Pyrazinamide: Abnormal liver function test, hyperuricemia.
Ethambutol HCl: Disturbances in sense organs and special senses, especially visual disturbances.
When overdosage occurs, immediately contact the physician to treat the patient accordingly.
Treatment: Gastric lavage is advised within the first 2-3 hrs after ingestion, but it should not be attempted until convulsions are under control.
Intensive supportive measures (eg, forced osmotic diuresis, hemodialysis, peritoneal dialysis, rapid control of acidosis, monitoring of fluid intake and output, obtaining of blood samples) should be instituted and individual symptoms treated as they arise (eg, treatment of convulsions).
